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  • Title: Effects of yohimbine on naloxone-induced antinociception in a rat model of inflammatory hyperalgesia.
    Author: Tsuruoka M, Hiruma Y, Matsutani K, Matsui Y.
    Journal: Eur J Pharmacol; 1998 May 08; 348(2-3):161-5. PubMed ID: 9652330.
    Abstract:
    Effects of the alpha2-adrenoceptor antagonist yohimbine on the antinociception produced by a low dose of naloxone were examined in a rat model of carrageenan-induced inflammation. In rats receiving saline prior to naloxone injection, the low dose of naloxone (5 microg/kg, i.p.) significantly prolonged paw withdrawal latency in response to noxious thermal stimuli for both the inflamed and the non-inflamed paws 4 h after carrageenan injection (6.0 mg in 0.15 ml saline). In rats receiving yohimbine, the low dose of naloxone failed to produce prolongation of paw withdrawal latencies 4 h after carrageenan, whereas naloxone produced antinociception 7 days after carrageenan. The results suggest that noradrenergic mechanisms are involved in naloxone-induced antinociception only in the early phase of carrageenan-induced inflammation.
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