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  • Title: Efficacy of a low-dose subcutaneous lisuride infusion in Parkinson's disease.
    Author: Hayashi R, Tako K, Makishita H, Koyama J, Yanagisawa N.
    Journal: Intern Med; 1998 May; 37(5):444-8. PubMed ID: 9652898.
    Abstract:
    Five parkinsonian patients with motor fluctuations and dyskinesia after long-term treatment with levodopa were treated with subcutaneous lisuride infusion (0.24-0.42 mg/day) together with oral levodopa for a mean period of 27 (range 13-36) months. All 5 patients showed marked initial improvement in mobility. Mild psychiatric side effects were observed in three patients; however, these side effects disappeared with reduction in the dosage of lisuride to 0.06 mg per day without a significant increase in motor fluctuations. A low dose of subcutaneous lisuride infusion with oral levodopa is an effective treatment for fluctuations of motor performance in parkinsonian patients without adverse psychiatric effects.
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