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  • Title: Determination of ropivacaine and [2H3]ropivacaine in biological samples by gas chromatography with nitrogen-phosphorus detection or mass spectrometry.
    Author: Engman M, Neidenström P, Norsten-Höög C, Wiklund SJ, Bondesson U, Arvidsson T.
    Journal: J Chromatogr B Biomed Sci Appl; 1998 May 08; 709(1):57-67. PubMed ID: 9653926.
    Abstract:
    Bioanalytical methods for determining the total concentration of the new local anaesthetic drug ropivacaine in blood plasma, urine and tissues are presented. Ropivacaine is a drug mainly used in connection with surgery and for post-operative pain relief. The biological samples were prepared using liquid-liquid extraction and analysed using capillary gas chromatography with nitrogen-phosphorus detection or mass spectrometry. The methods are highly selective and reliable with a between-day precision, given as the relative standard deviation, generally below 6%. More than 20000 samples have been analysed using the methods described.
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