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  • Title: Drug exposure and the acquisition and retention of a conditioned taste aversion.
    Author: Riley AL, Jacobs WJ, LoLordo VM.
    Journal: J Comp Physiol Psychol; 1976 Aug; 90(8):799-807. PubMed ID: 965528.
    Abstract:
    Two experiments examined the effects of preexposure and postexposure to a drug on the acquisition and retention of a conditioned taste aversion induced by that drug. Experiment 1 demonstrated that although drug preexposure attenuated a subsequent conditioned aversion, repeated taste-drug pairings reversed the initial attenuation effect and resulted in nearly complete avoidance of consumption. Experiment 2, however, demonstrated that drug postexposure did not alter a previously established conditioned aversion, although the postexposure experiences were effective in attenuating a conditioned aversion to a second novel solution. It was suggested that conditioned aversions are mediated by ACTH and that preexposure to a drug results in tolerance to that drug, yielding a smaller ACTH response and thereby a weaker aversion.
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