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  • Title: Maternal and viral factors in vertical transmission of HIV-1 subtype E.
    Author: Sutthent R, Foongladda S, Chearskul S, Wanaprapa N, Likanonskul S, Kositanont U, Riengrojpitak S, Sahapong S, Wasi C.
    Journal: Southeast Asian J Trop Med Public Health; 1997 Dec; 28(4):689-98. PubMed ID: 9656387.
    Abstract:
    Vertical transmission of HIV-1 is caused by multifactorial factors. To access the relationship of viral factors involving in perinatal transmission of HIV-1 subtype E, which is the predominant type in Thailand, plasma viral load, blood CD4+ lymphocyte level, heteroduplex mobility, and V3 sequence of the HIV-1 envelope gene were studied in 32 transmitting and 25 non-transmitting mothers. We found that HIV-1 subtype E vertical transmission was strongly associated with high maternal plasma viral RNA (> 4 x 10(4) copies/ml) and high genetic diversity of envelope gene determined by heteroduplex mobility (< 0.9). The variation of nucleotide sequences in envelope gene of subtype E vertical transmission could not determine in V3 region. Hence, plasma viral load and heteroduplex mobility can be used as prediction factors in vertical transmission of HIV-1 subtype E.
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