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  • Title: Enzyme replacement therapy decreases hypergammaglobulinemia in Gaucher's disease.
    Author: Deibener J, Kaminsky P, Jacob C, Dousset B, Klein M, Duc M.
    Journal: Haematologica; 1998 May; 83(5):479-80. PubMed ID: 9658738.
    Abstract:
    We report the effects of enzyme replacement therapy in a patient with Gaucher's disease associated with a monoclonal gammopathy. Alglucerase induces a linear decline in immunoglobulin and beta 2-microglobulin levels. This observation suggests that this treatment decreases the chronic antigenic stimulation commonly found in Gaucher's disease.
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