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  • Title: Closed percutaneous pleural brushing: a new method for diagnosis of malignant pleural effusions.
    Author: Emad A, Rezaian GR.
    Journal: Respir Med; 1998 Apr; 92(4):659-63. PubMed ID: 9659533.
    Abstract:
    Pleural fluid cytology and pleural biopsy are the two most commonly employed diagnostic tests for malignant pleural effusions. Here, we have introduced a new diagnostic method, namely closed percutaneous pleural brushing, and have compared its diagnostic yield with those of pleural fluid cytology and pleural biopsy in patients with suspected malignant pleural effusion. Forty-three consecutive patients with suspected malignant pleural effusion underwent thoracentesis, closed pleural brushing and closed pleural biopsy using Cope's pleural biopsy needle and a cytological brush (BC-10C) which was introduced into the pleural cavity through the cannula of the same needle. All the samples were sent for bacteriological and cytological studies. Patients had a mean follow-up period of 9.28 +/- 1.87 months during which seven cases whose entire studies were non-diagnostic underwent thoracotomy and open pleural biopsy. Thirty-four cases were finally documented to have malignancy. Closed pleural brushing was positive in 31 (91%) of cases. This was superior to that achieved by either pleural fluid cytology (67%) (P = 0.01) or pleural biopsy (58%) (P = 0.002). No pneumothorax or other major complications were encountered with this method. Closed pleural brushing via Cope's needle is a relatively safe, simple and well-tolerated technique with a high diagnostic yield for patients with malignant pleural effusion. It may substitute for other more invasive and more expensive procedures such as thoracoscopy and thoracotomy in this group of patients.
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