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  • Title: Imaging small pulmonary ischemic lesions after radioactive carbon monoxide inhalation.
    Author: Taplin GV, Chopra SK, MacDonald NS, Elam D.
    Journal: J Nucl Med; 1976 Oct; 17(10):866-71. PubMed ID: 966052.
    Abstract:
    A new method is described for imaging small ischemic regions in the lung immediately after a single breath of radioactive carbon monoxide (11CO). A tungsten-collimated scintillation camera is used to visualize the 0.51-MeV annihilation photons due to the 11C. In normal dogs the entire field is cleared of 11CO within 10 sec. However, in dogs with experimentally occluded 2-mm-diam segmental arteries, the ischemic but well-ventilated segment appears as a region of persistent high radioactivity, due most likely to temporary entrapment of 11CO-labeled red blood cells in the ischemic region. This technique also provides a simple noninvasive means for instantly labeling the systemic circulation without left heart catheterization.
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