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  • Title: Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
    Author: Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T.
    Journal: Mol Cell; 1998 Mar; 1(4):507-18. PubMed ID: 9660935.
    Abstract:
    We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.
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