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  • Title: Qualitative changes of anticonvulsant action of felbamate during development in rats.
    Author: Haugvicová R, Kubová H, Mares P.
    Journal: Brain Dev; 1998 Jun; 20(4):222-6. PubMed ID: 9661966.
    Abstract:
    The anticonvulsant action of felbamate (25, 50, 100 and 150 mg/kg i.p.) was tested against motor seizures induced by pentylenetetrazol in five age-groups of rats (7, 12, 18, 25 and 90 days old). In adult rats, felbamate suppressed generalized tonic-clonic seizures leaving intact minimal clonic seizures. In all groups of rat pups felbamate exhibited a specific action against the tonic phase of generalized tonic-clonic seizures. In addition, the highest dose of felbamate was found to suppress minimal seizures in 18-day-old rats. The changes of felbamate action during ontogeny might be due to multiple mechanisms of anticonvulsant action with an uneven developmental profile.
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