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  • Title: Complex formation between calsequestrin and the ryanodine receptor in fast- and slow-twitch rabbit skeletal muscle.
    Author: Murray BE, Ohlendieck K.
    Journal: FEBS Lett; 1998 Jun 16; 429(3):317-22. PubMed ID: 9662440.
    Abstract:
    Linkage between the high-capacity Ca2+-binding protein calsequestrin and the ryanodine receptor is proposed to be essential for proper Ca2+-release during skeletal muscle excitation-contraction coupling. However, no direct biochemical evidence exists showing a connection between these high-molecular-mass complexes in native skeletal muscle membranes. Here, using immunoblot analysis of chemically crosslinked membrane vesicles enriched in triad junctions, we have demonstrated that a very close neighborhood relationship exists between calsequestrin and the ryanodine receptor in both main fiber types. Hence, the luminal Ca2+-reservoir complex appears to be directly coupled to the membrane Ca2+-release complex and oligomerization seems to be of functional importance.
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