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  • Title: Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract.
    Author: Frayne J, Jury JA, Barker HL, Perry AC, Jones R, Hall L.
    Journal: Mol Hum Reprod; 1998 May; 4(5):429-37. PubMed ID: 9665629.
    Abstract:
    A large number of sequence-related, cysteine-rich membrane proteins containing metalloproteinase-like and disintegrin-like domains (the MDC protein family) have been identified in mammalian tissues from a variety of species. Previous studies in the macaque (Macaca fascicularis) have led to the cDNA cloning and sequence analysis of a number of MDC proteins which are abundantly expressed in the male reproductive tract. We now describe the distribution of seven of these macaque MDC transcripts in a range of different tissues. This description includes a novel macaque testis-derived MDC, tMDC III, whose full-length sequence is reported for the first time. In addition, polyclonal antisera have been used to localize a number of these MDC proteins to spermatogenic cells in testis sections, and to demonstrate their processing on the sperm surface during epididymal transit.
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