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  • Title: Effects of inner hair cell loss on inferior colliculus evoked potential thresholds, amplitudes and forward masking functions in chinchillas.
    Author: McFadden SL, Kasper C, Ostrowski J, Ding D, Salvi RJ.
    Journal: Hear Res; 1998 Jun; 120(1-2):121-32. PubMed ID: 9667436.
    Abstract:
    The effects of outer hair cell (OHC) loss on evoked potential (EVP) thresholds, amplitudes and forward masking (FWM) functions have been fairly well characterized. In contrast, the effects of inner hair cell (IHC) losses are largely unknown, primarily due to the difficulty of producing selective IHC lesions. Recent studies have shown that IHCs of the chinchilla are preferentially damaged by the anticancer drug, carboplatin. In this study, we administered a single 100 mg/kg dose of carboplatin to four chinchillas, to examine the effects of IHC lesions on EVPs measured from the inferior colliculus (IC-EVPs). Thresholds and amplitude functions were measured for 0.25-16 kHz tone bursts, and FWM functions were measured at 1, 2 and 4 kHz, using masker probe intervals of 2, 5, 10, 20, 40 and 80 ms, before and 1-2 months after carboplatin treatment. Histology revealed IHC lesions ranging from approximately 15 to 90%, with virtually no loss of OHCs. Surprisingly, even massive IHC lesions were not associated with elevations of IC-EVP thresholds. IC-EVP amplitudes at suprathreshold levels were sometimes depressed, sometimes enhanced, and in some cases unchanged. IHC lesions increased susceptibility to FWM, particularly at intermediate (10-20 ms) masker-probe intervals, without significantly changing the overall time course of FWM. The results provide new perspectives on the contribution of IHCs to FWM, and on the ability of the central auditory system to adapt to a significant reduction of neural input from the cochlea.
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