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  • Title: Low-density lipoprotein receptor genotype-dependent response to cholesterol lowering by combined pravastatin and cholestyramine in familial hypercholesterolemia.
    Author: Kajinami K, Yagi K, Higashikata T, Inazu A, Koizumi J, Mabuchi H.
    Journal: Am J Cardiol; 1998 Jul 01; 82(1):113-7. PubMed ID: 9671018.
    Abstract:
    We compared the effects of cholesterol-lowering therapy on 2 patient groups genetically defined as heterozygous for familial hypercholesterolemia (FH), 5 with a deletion of exon 15 (FH(Tonami-1)), and 7 with a point mutation at codon 664 (FH(Kanazawa-2)). There were significant differences in both serum and low-density lipoprotein cholesterol reductions between the 2 groups after combination therapy with pravastatin and cholestyramine, and the overall effect of genotype on serial changes in both was significant.
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