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  • Title: Locus coeruleus-mediated inhibition of chemosensory responses in the rat nucleus tractus solitarius is mediated by alpha2-adrenoreceptors.
    Author: Pérez H, Ruiz S, Laurido C, Hernández A.
    Journal: Neurosci Lett; 1998 Jun 12; 249(1):37-40. PubMed ID: 9672383.
    Abstract:
    It is known that electrical and L-glutamate stimulation of the locus coeruleus (LC) reduce the multiunit activity evoked in the nucleus of the tractus solitarius (NTS) by cyanoboro-hydride. In the present study, rats anaesthetised with urethane were microinjected with noradrenergic antagonists into the NTS, to test whether the inhibitory effects of LC stimulation on cyanide-evoked discharge in the NTS were mediated by noradrenaline. Microinjection of yohimbine into the NTS (0.2, 0.6, 1.8, 5.4 nmol) induced dose-dependent reduction of the inhibitory effect of LC stimulation on NTS neurones, while prazosin produced no effect. The results indicate that LC-induced inhibition of the cyanide-evoked discharge in the NTS is mediated by endogenous noradrenaline release acting on alpha2-adrenoreceptors.
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