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  • Title: Electrical stimulation of the sacral dorsal gray commissure evokes relaxation of the external urethral sphincter in the cat.
    Author: Blok BF, van Maarseveen JT, Holstege G.
    Journal: Neurosci Lett; 1998 Jun 12; 249(1):68-70. PubMed ID: 9672391.
    Abstract:
    Stimulation of the pontine micturition center (PMC) results in micturition, i.e. an immediate relaxation of the urethral sphincter and a contraction of the detrusor muscle of the bladder. The PMC generates the bladder contraction by way of a direct excitatory pathway to the parasympathetic bladder motoneurons in the sacral cord. The idea is that the PMC produces the relaxation of the urethral sphincter via direct projections to GABAergic neurons in the dorsal gray commissure (DGC), which, in turn, inhibit the urethral sphincter motoneurons. According to this hypothesis, electrical stimulation in the DGC in three cats should result in relaxation of the urethral sphincter. The results were in total agreement with this concept. During DGC stimulation a sharp decrease of the urethral pressure was found, the strength of which depended completely on the amplitude of the electrical stimulation.
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