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  • Title: Cross-reactivity of anti-10kD heat shock protein antibodies in leprosy and tuberculosis patients.
    Author: Rojas RE, Demichelis SO, Giménez MF, Molinari ML, Segal-Eiras A.
    Journal: Medicina (B Aires); 1997; 57(5):581-6. PubMed ID: 9674227.
    Abstract:
    The response to recombinant 10-kD heat shock protein (HSP) of Mycobacterium leprae (rML10) was evaluated by indirect ELISA in sera from leprosy patients, household contacts, tuberculosis patients and healthy controls in a leprosy-endemic area in the North East of Argentina. Some technical parameters were analyzed: within-assay and between-assay variability, dose-response curves and detectability indexes (specificity and sensitivity) of ELISA applied to measure anti-10 kDa antibodies. High levels of these antibodies have already been reported in positive bacilloscopy patients; herein we have also demonstrated that tuberculosis patients sera cross-react with this M. leprae antigen. This test seems to have a low sensitivity and specificity for leprosy detection; it confirms that antibodies against highly conserved HSP antigens are important in the polyclonal response against mycobacterial epitopes in leprosy as well as in tuberculosis.
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