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  • Title: [Intravascular malignant B-cell lymphomatosis with renal glomerular involvement: a case].
    Author: Charasse C, Boulahrouz R, Le Moal S, Bousser J, Pasquiou A, Le Cacheux P, Ang KS, Simon P, Ramée MP.
    Journal: Nephrologie; 1998; 19(4):211-5. PubMed ID: 9675761.
    Abstract:
    We report a case of intravascular malignant lymphomatosis observed in a 71 year-old male and characterised by the presence of a proteinuria in relation to the specific intraglomerular localisation. This malignant lymphoma, usually of the B phenotype, is rare and affects predominantly the central nervous system and the skin. Neoplastic cells home selectively to endothelium. Histological renal infiltration is frequent but a glomerular localisation, with proteinuria, is rare. The mechanism whereby lymphocytes home to endothelium cells is unclear but it could be related to the expression of lymphocyte-endothelium adhesion molecules. When present the nephrotic syndrome is associated with minimal change disease.
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