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  • Title: Model to study long-term effects of propoxyphene napsylate (darvon-N) on narcotic-dependent mice.
    Author: Hostetler RM, Reinhard J, Peterson GR.
    Journal: Res Commun Chem Pathol Pharmacol; 1976 Sep; 15(1):75-88. PubMed ID: 9676.
    Abstract:
    Five different strains of mice were investigated for their suitability to serve as models for the study of long-term effects of propoxyphene napsylate (PN) on narcotic-dependent mice. The NIH/Swiss outbred strain proved to be most suitable because of its high liability to manifest physical dependence on morphine. Following removal of subcutaneously-implanted morphine pellets from the mice, the incidence of spontaneous withdrawal jumping was used as a quantifiable criterion of physical dependence. An orally administered suspension of PN suppressed the withdrawal jumping in a dose-dependent manner. However, chronic (daily) administration of PN at doses high enough to prevent withdrawal jumping was characterized by a high degree of toxicity.
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