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  • Title: Is there an optimal time to administer methotrexate in the treatment of rheumatoid arthritis?
    Author: Carpentier N, Bertin P, Marquet P, Sabot C, Bonnet C, Debord J, Lachâtre G, Trèves R.
    Journal: J Rheumatol; 1998 Jul; 25(7):1270-5. PubMed ID: 9676755.
    Abstract:
    OBJECTIVE: To determine the optimal time to administer methotrexate (MTX) in rheumatoid arthritis (RA). METHODS: In a crossover study 23 patients were administered MTX intramuscularly at either 10 AM or 6 PM. A 2 week interval separated the 2 injections. MTX concentrations were measured using a fluorescence polarization immunoassay. Pharmacokinetic variables were estimated using a Bayesian approach. The morning and evening schedules were compared using analysis of variance to determine the optimal time of injection. RESULTS: No statistical difference was found in the pharmacokinetics of MTX according to hour of injection. A difference in the creatinine clearance, however, was observed in the samples obtained at noon and 8 PM, but clearance of MTX was unchanged. CONCLUSION: Pharmacokinetic variables suggest that MTX can be administered either in the morning (10 AM) or evening (6 PM) in the treatment of RA.
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