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  • Title: Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
    Author: Orjala J, Mian P, Rali T, Sticher O.
    Journal: J Nat Prod; 1998 Jul; 61(7):939-41. PubMed ID: 9677279.
    Abstract:
    Fractionation of the petroleum ether extract from the leaves of Piper gibbilimbum collected in Papua New Guinea afforded four new alkenylphenols, gibbilimbols A-D (1-4). The structures of the isolates were elucidated by spectroscopic methods, mainly 1D- and 2D-NMR spectroscopy. Gibbilimbols A-D were found to be toxic to brine shrimp with an LC50 of approximately 5 microg/mL. Gibbilimbols A-D were further found to be cytotoxic toward KB nasopharyngal carcinoma cells (ED50 7.8-2.1 microg/mL). All isolates also showed antibacterial activity toward Staphylococcus epidermidis and Bacillus cereus.
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