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  • Title: Effect of leukocytic endogenous mediator (LEM) on zinc absorption in the rat.
    Author: Pekarek RS, Evans GW.
    Journal: Proc Soc Exp Biol Med; 1976 Sep; 152(4):573-5. PubMed ID: 967889.
    Abstract:
    Leukocytic endogenous mediator (LEM) was shown to produce a significant increase in the intestinal absorption of zinc within 7 hr after its administration to normal rats. Consistent with earlier studies, LEM also produced a significant decrease in the plasma zinc concentration and an increased hepatic uptake of this metal which further demonstrates that LEM may be a key intermediate in altering zinc homeostasis during inflammation.
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