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  • Title: Passive immunization reduces immunity that results from simultaneous active immunization against tick-borne encephalitis virus in a mouse model.
    Author: Kreil TR, Burger I, Attakpah E, Olas K, Eibl MM.
    Journal: Vaccine; 1998; 16(9-10):955-9. PubMed ID: 9682343.
    Abstract:
    Concomitant administration of an antigen and antibodies of the respective specificity has been shown to result in reduced levels of actively produced antibodies. This has also recently been observed in a clinical trial on simultaneous passive and active immunization against tick-borne encephalitis virus (TBEV). In the current study the influence of simultaneous passive and active immunization on vaccine induced protective immunity against TBEV has been evaluated in a mouse model. Two immunizations with licensed whole-killed TBEV vaccines gave close to complete protection. Administration of human or mouse TBEV antibodies together with the first vaccine dose resulted in a significant reduction of vaccine induced protection against TBEV challenge. This effect was even more pronounced than that observed earlier on the levels of vaccine induced antibody.
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