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  • Title: Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats.
    Author: Ino-ue M, Ohgiya N, Yamamoto M.
    Journal: Brain Res; 1998 Aug 03; 800(2):319-22. PubMed ID: 9685690.
    Abstract:
    The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body weight) AG treatment. High dose (100 mg kg-1 body weight) AG completely prevented myelinated nerve fiber atrophy. These findings indicated that nonenzymatic glycation contributes to the development of optic nerve changes in diabetic rats.
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