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  • Title: Down-modulation of a novel Bax-associated protein during apoptosis in normal mature B lymphocytes.
    Author: He H, Hershberger PA, McCarthy SA.
    Journal: J Immunol; 1998 Aug 01; 161(3):1176-82. PubMed ID: 9686577.
    Abstract:
    We have recently characterized a novel 16-kDa Bax-associated protein. In this study, we investigate the regulation of this protein's expression during in vitro induction of apoptosis in mature splenic B cells. A panel of biochemically distinct apoptotic stimuli induced the dramatic down-modulation of the 16-kDa protein in B cells; this down-modulation was rapid, and did not require DNA fragmentation. Reciprocally, stimuli that induced protection from apoptosis prevented down-modulation of the 16-kDa protein. These regulatory effects were specific, since Bcl-2 and Bax protein levels were not similarly modulated. Stimuli that reduce expression of the 16-kDa protein may therefore act indirectly to increase the proapoptotic activity of Bax, perhaps by altering Bax binding to other cellular proteins.
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