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  • Title: Increased serum trypsin and elastase-1 levels in patients undergoing L-asparaginase therapy.
    Author: Shimizu T, Yamashiro Y, Igarashi J, Fujita H, Ishimoto K.
    Journal: Eur J Pediatr; 1998 Jul; 157(7):561-3. PubMed ID: 9686816.
    Abstract:
    UNLABELLED: Although there is abundant literature on the association of L-asparaginase and acute pancreatitis in patients undergoing chemotherapy, few studies have investigated the usefulness of pancreatic enzyme measurement in the early diagnosis of L-asparaginase-induced acute pancreatitis. We measured levels of serum pancreatic enzymes before, during, and after L-asparaginase therapy in nine children with acute lymphocytic leukaemia or non-Hodgkin lymphoma. Serum levels of amylase, pancreatic isoamylase, and lipase did not change between the 1st and 30th day of L-asparaginase administration. However, the serum trypsin and elastase- levels, 10 and 20 days after beginning L-asparaginase therapy, were significantly higher than those prior to therapy. CONCLUSION: L-asparaginase may induce subclinical pancreatitis and the estimation of serum trypsin and elastase-1 may be useful in the early diagnosis of L-asparaginase-induced acute pancreatitis.
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