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  • Title: Anxiolytic and memory improving effects of moclobemide.
    Author: Nowakowska E, Chodera A, Kus K, Rybakowski J.
    Journal: Arzneimittelforschung; 1998 Jun; 48(6):625-8. PubMed ID: 9689417.
    Abstract:
    The anxiolytic and memory enhancing effects of moclobemide (p-chloro-N-(2-morphinoethyl)benzamide, CAS 71320-77-9, Ro 11-1163), a reversible and selective monoamine A oxidase inhibitor, were investigated in rats. It was found that the drug had an anxiolytic activity lasting in chronic experiments over 2 weeks. The used dose of the drug did not change animal locomotion in activity cages. In memory experiments (food finding time in maze), moclobemide exerted a favorable effect only after a single administration. In rats with scopolamine-impaired memory, moclobemide attenuated the effects of scopolamine in single and chronic experiments.
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