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  • Title: Pilot evaluation of hypnotic medication during acute traumatic stress response.
    Author: Mellman TA, Byers PM, Augenstein JS.
    Journal: J Trauma Stress; 1998 Jul; 11(3):563-9. PubMed ID: 9690193.
    Abstract:
    Early intervention aimed at secondary prevention is a high priority for posttraumatic stress disorder (PTSD) research. Disrupted sleep may have a role in the initiation and maintenance of PTSD. Three of the participants were recruited from a surgical trauma service, and one had sought treatment in a psychiatric setting. All were within 1-3 weeks of trauma exposure and had acute PTSD symptoms that included disturbed sleep. Temazepam, a benzodiazepine hypnotic, was administered for 5 nights, tapered for 2 nights, and then discontinued. Evaluations 1-week after the medication had been discontinued revealed improved sleep and reduced PTSD severity. These observations suggest an approach that may be clinically useful and a need for more systematic trials.
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