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  • Title: High prevalence of parvovirus B19 IgG antibodies among Dutch hemophilia patients.
    Author: Mauser-Bunschoten EP, Zaaijer HL, van Drimmelen AA, de Vries S, Roosendaal G, van den Berg HM, Lelie PN.
    Journal: Vox Sang; 1998; 74(4):225-7. PubMed ID: 9691402.
    Abstract:
    BACKGROUND AND OBJECTIVES: Human parvovirus B19 is a potential risk to hemophiliac patients receiving blood products. MATERIALS AND METHODS: To determine the prevalence of the corresponding antibody in patients with hemophilia A or B von Willebrand's disease, we tested 326 hemophilia patients for anti-B19 IgG. The results were compared with those of 203 age-matched controls (male blood donors and children). RESULTS: The overall prevalence of B19 IgG in the hemophilia patients was 302/326, and in the controls 123/203. Below the age of 10, hemophilia patients had a higher prevalence of B19 IgG (76%, 42/55) than the controls (23%, 11/48; p < 0.00001). In those below the age of 5 who had been treated exclusively with monoclonally purified concentrate, it made no difference whether the product was pasteurized or solvent-detergent treated. There was significantly lower incidence in patients who were rarely treated. CONCLUSION: Parvovirus B19 if frequently transmitted in blood products. Existing virus-inactivating methods do not prevent transmission.
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