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  • Title: [Stress and immunoallergy].
    Author: Chihara J.
    Journal: Rinsho Byori; 1998 Jun; 46(6):587-92. PubMed ID: 9691768.
    Abstract:
    We have previously reported that hyperresponsiveness in the restriction stress guinea pig group as compared to that in controls was observed. On the other hand, adhesion molecules, especially intercellular adhesion molecule-1 (ICAM-1), are considered to play an important role in inflammatory processes in allergic and immune reactions such as bronchial asthma. Therefore, in this study, our investigation was designed to clarify whether stress is involved in adhesion molecules expression on inflammatory cells and endothelial cells (EC). Results were as follows: 1) IL-1, which is considered to play an important role in psychoneuroimmunological phenomena, induced ICAM-1 expression on human EC. 2) Moreover, PAF and PF 4, which may be striking chemotactic agents and activating agents for eosinophils, also induced ICAM-1 expression on human EC. 3) The leukocyte adherence to plasma coated glass in the electric shock stress guinea pig model was augmented as compared to that of controls. 4) Eosinophil counts as well as eosinophil percentages in adherent leukocytes in the electric shock stress group were greater than those of controls. 5) Moreover, leukocyte adherence to autologous bronchial ciliary cells was also augmented in the stress group as compared to that of controls. In conclusion taken together, stress might be involved in adhesion molecules expression resulting in acceleration of allergic inflammatory reactions such as bronchial asthma.
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