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  • Title: [Effect of prenatal treatment with diethylstilbestrol on 1,2-dimethylhydrazine-induced carcinogenesis in male CBA mice].
    Author: Trukhanova LS, Samoĭlov DV, Turusov VS.
    Journal: Vopr Onkol; 1998; 44(3):342-5. PubMed ID: 9695784.
    Abstract:
    Female CBA mice were injected 1 mg/kg diethylstilbestrol (DES) on day 17 of gestation. Their male progeny received 15 weekly injections of 1,2-dimethylhydrazine (DMH) starting from the age of 2 months. Prenatal treatment with DES was followed by a significant acceleration and higher frequency of DMH-induced renal adenomas and renal capsule sarcomas in males. Tumor-induction was significantly enhanced by androgen effect. This was matched by a higher frequency of induced tumors of the large bowel. The increased frequency of androgen-dependent renal malignancies, served as indirect evidence of hyperandrogenization being stimulated in CBA male mice by prenatal treatment with DES.
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