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  • Title: Direct cardiac effects in isolated perfused rat hearts measured at increasing concentrations of morphine, alfentanil, fentanyl, ketamine, etomidate, thiopentone, midazolam and propofol.
    Author: Süzer O, Süzer A, Aykaç Z, Ozüner Z.
    Journal: Eur J Anaesthesiol; 1998 Jul; 15(4):480-5. PubMed ID: 9699107.
    Abstract:
    The direct cardiac effects of morphine, alfentanil, ketamine, etomidate, thiopentone, midazolam and propofol were measured in isolated Wistar rat hearts. Experiments were performed using a multiple columnar Langendorff apparatus and the hearts were perfused with a modified Tyrode solution under constant pressure. Each drug was applied from a different column in rising concentrations at 5-min intervals. Dose ranges were chosen to compare effects at sub-clinical, clinically relevant and more than clinical concentrations. Six rat hearts were chosen at random for each drug. Only thiopentone reduced contractile force at a clinically relevant concentration: measured as g contractility per g heart weight-1 (mean +/- standard deviation), base-line contractility was 8.8 +/- 2.4, and contractility at 10(-4) mol litre-1 thiopentone was 7.1 +/- 1.5 (P < 0.01). Alfentanil was the only drug to have no significant effect on the isolated heart at any concentration. Propofol was not cardiodepressant at clinically relevant concentrations, but had a lower therapeutic range than the other drugs.
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