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  • Title: Regulation of progesterone biosynthesis in human placental mitochondria by Krebs cycle metabolites.
    Author: Klimek J, Boguslawski W, Tialowska B, Zelewski L.
    Journal: Acta Biochim Pol; 1976; 23(2-3):185-92. PubMed ID: 970033.
    Abstract:
    1. 2-Oxoglutarate, succinate, fumarate, malate and citrate, cis-aconitate and isocitrate stimulate conversion of cholesterol to progesterone in human placental mitochondria. 2. The stimulatory effect of dicarboxylic and tricarboxylic acids depends on the activity of malate dehydrogenase (decarboxylating) (NADP+) (EC 1.1.1.40) and isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), respectively.
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