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  • Title: The glycerylphosphorylcholine content of the rat epididymis after injecting alpha-chlorohydrin and ligating the vasa efferentia.
    Author: Brown-Woodman PD, Sale D, White IG.
    Journal: Acta Eur Fertil; 1976 Jun; 7(2):155-62. PubMed ID: 970074.
    Abstract:
    The concentration of GPC in the 4 segments (initial segment, caput, corpus and cauda) of the rat epididymis was examined at various times (4 hours. 2, 5, 10 and 20 days) following injection of a lesion-forming dose (90 mg/kg body weight) of alpha-chlorohydrin and bilateral ligation of the vasa efferentia. There was a reduction in the overall GPC concentration of the epididymis 2 days after both treatments and a further decrease until 20 days when a slight increase occurred. It is suggested that a lesion-forming dose of alpha-chlorohydrin, like ligation of the vasa efferentia, could inhibit the synthesis and/or release of GPC within the epididymis by blocking off androgen supply in the testicular fluid.
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