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  • Title: Endogenous motilin and lower esophageal sphincter pressure in man: clue to an association.
    Author: Domschke W, Lux G, Mitznegg P, Rösch W, Domschke S.
    Journal: Acta Hepatogastroenterol (Stuttg); 1976; 23(4):274-5. PubMed ID: 970085.
    Abstract:
    In man (n = 5), after intraduodenal instillation of 50 ml of 0.1 N hydrochloric acid the lower esophageal sphincter pressure (LESP) and plasma motilin concentrations rise concomitantly exceeding basal by about 80% (p less than 0.025) and 90% (p less than 0.05), respectively, at 3 to 4 minutes. These results suggest that the increase in LESP after duodenal acidification may be brought about by endogenously released motilin.
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