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  • Title: [Characterization of ligand-dependent transactivation regions of the human vitamin D receptor].
    Author: Nakajima S.
    Journal: Nihon Rinsho; 1998 Jul; 56(7):1717-21. PubMed ID: 9702043.
    Abstract:
    The 1,25-dihydroxyvitamin D receptor (VDR) belongs to the nuclear hormone receptor family. Mutational analysis revealed that the carboxyl-terminal region between leucine-417 and glutamic acid-420 of the human VDR is essential for the ligand-dependent transactivation. Mutant VDR at this AF-2 region exhibits only weak suppressive effect on the transactivation via the wild type receptor compared to the estrogen and vitamin A receptors, which confer the strong dominant negative effect. Using the AF-2 mutant VDR protein, we demonstrated a 65kD nuclear protein, which binds to the AF-2 region of the human VDR in a ligand dependent manner.
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