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  • Title: A low T3 syndrome in diabetic ketoacidosis.
    Author: Naeije R, Golstein J, Clumeck N, Meinhold H, Wenzel KW, Vanhaelst L.
    Journal: Clin Endocrinol (Oxf); 1978 Jun; 8(6):467-72. PubMed ID: 97034.
    Abstract:
    The pituitary-thyroid axis was investigated in nineteen euthyroid patients with severe diabetic ketoacidosis. A 'low T3 syndrome' was found, with the following characteristics: lowered serum concentrations of triiodothyronine (T3), increased reverse triiodothyronine (rT3), slightly low thyroxine (T4), normal thyrotrophin (TSH), slightly increased triiodothyronine uptake (RT3U) values, and a blunted TSH response to thyrotrophin-releasing hormone (TRH). These disturbances in thyroid-function tests required several days good control of the diabetes to be corrected, at least partially. The data suggest the presence of an abnormal extrathyroidal T4 metabolism as well as a pituitary defect. Caution is recommended in the interpretation of thyroid-function tests during and several days after the treatment of diabetic ketoacidosis.
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