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  • Title: [Bax and Bcl-2 expression predict response to radiotherapy in human cervical cancer].
    Author: Harima Y, Oka A, Nagata K, Harima K, Tanaka Y, Shikata N.
    Journal: Gan To Kagaku Ryoho; 1998 Jul; 25(9):1273-7. PubMed ID: 9703806.
    Abstract:
    To establish a new predictor of the outcome of treatment for human cervical carcinoma, we investigated the relationship between the expression of the Bax and Bcl-2 proteins and the response to radiotherapy after administration of 10.8 Gy. A total of 44 patients with uterine cervical carcinoma were treated with definitive radiotherapy. On univariate analysis, Bax and Bcl-2 protein expression prior to radiotherapy did not correlate with survival. Increased Bax expression after 10.8 Gy correlated with good survival (p = 0.003). In contrast, increased Bcl-2 expression after 10.8 Gy correlated with poor survival (p < 0.0001). On multivariate analysis, Bcl-2 expression after 10.8 Gy of radiation was the most important predictor of treatment outcome. The levels of Bax and Bcl-2 expression after 10.8 Gy of radiotherapy are useful prognostic markers in patients with human cervical carcinoma.
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