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  • Title: [Importance of the study of the expression of MIB-1 (Ki-67) for the diagnosis of endocervical glandular lesions].
    Author: Leteurtre E, Boman F, Farine MO, Leroy JL, Gosselin B.
    Journal: Ann Pathol; 1998 Jul; 18(3):172-7. PubMed ID: 9706342.
    Abstract:
    The morphological criteria for the diagnosis of endocervical atypia and dysplasia are variably defined. Diagnosis is difficult. MIB-1 (Ki-67) cell proliferation-associated antigen was detected retrospectively by immunohistochemistry in 230 cervical cone specimens. The percentage of MIB-1 positive cells was 1 to 25% (median 2%) and limited to small hot spots in normal and subnormal glands (140 cases). It was 1 to 30% (median 4%) in endometrioid metaplasia and microglandular hyperplasia (55 cases); 30 to 60 (median 40%) and limited to 1-3 glands in atypia (24 cases); 45 to 60% (median 50%) and diffusely distributed in dysplasia (5 cases). In situ (3 cases) and invasive (3 cases) adenocarcinomas were characterized by a high% (> 60) of MIB-1 positive cells.
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