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  • Title: Platelet monoamine oxidase B activity in "de novo" and l-dopa treated parkinsonian patients and controls.
    Author: Kuhn W, Müller T, Gerstner A, Winkel R, Goetz ME.
    Journal: Can J Neurol Sci; 1998 Aug; 25(3):249-51. PubMed ID: 9706728.
    Abstract:
    OBJECTIVE: Previous studies demonstrated controversial results regarding monoamine oxidase B (MAO-B) activity in platelets in the periphery in parkinsonian patients (PD). SUBJECTS AND METHODS: Therefore we determined platelet MAO-B activity in three age- and sex-matched groups of 17 untreated, so called "de novo" patients with Parkinson's disease (PD), 17 parkinsonian patients, receiving levodopa, and 17 controls by a radio enzymatic assay. RESULTS: No significant differences of MAO-B activity appeared. CONCLUSION: This result suggests that phenotypic determination of MAO-B activity in platelets may not be used as peripheral marker in PD and that levodopa treatment does not alter MAO-B activity in the periphery.
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