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  • Title: [Micromethod of diazepam determination in the blood by gas-liquid chromatography. Application in neonatal pharmacology].
    Author: Scagliola N, Julien R, Dreux C.
    Journal: Ann Biol Clin (Paris); 1976; 34(1):27-32. PubMed ID: 970696.
    Abstract:
    We propose a micromethod of diazepam determination on 0,1 ml of whole blood. The extraction is made with n-heptane for the isolation of diazepam in presence of principal metabolites. For the usual concentrations, the precision is about 3 per cent; at the detection limite, 0,05 mug/ml, it is about 20 per cent. With this method we studied the pharmacokinetics of diazepam in neonate with convulsive diseases in comparison with electroencephalogram.
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