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  • Title: The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.
    Author: Leu JY, Chua PR, Roeder GS.
    Journal: Cell; 1998 Aug 07; 94(3):375-86. PubMed ID: 9708739.
    Abstract:
    The hop2 mutant of S. cerevisiae displays a novel phenotype: meiotic chromosomes form nearly wild-type amounts of synaptonemal complex, but most chromosomes are engaged in synapsis with nonhomologous partners. The meiosis-specific Hop2 protein localizes to chromosomes prior to and during synapsis and in the absence of the double-strand breaks that initiate recombination. hop2 strains sustain a wild-type level of meiotic double-strand breaks, but these breaks remain unrepaired. The hop2 mutant arrests at the pachytene stage of meiotic prophase with the RecA-like protein Dmc1 located at numerous sites along synapsed chromosomes. We propose that the Hop2 protein functions to prevent synapsis between nonhomologous chromosomes.
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