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  • Title: The efficacy of focal laser therapy in radiation-induced macular edema.
    Author: Hykin PG, Shields CL, Shields JA, Arevalo JF.
    Journal: Ophthalmology; 1998 Aug; 105(8):1425-9. PubMed ID: 9709753.
    Abstract:
    OBJECTIVE: The purpose of the study was to determine whether focal laser therapy improves or prevents deterioration of visual acuity in radiation-induced macular edema. DESIGN: Retrospective review. PARTICIPANTS: The chart review of 19 patients. INTERVENTION: Comparison of 19 patients with radiation-induced macular edema secondary to radioactive scleral plaque application for choroidal melanoma managed by focal laser therapy with a matched group of 23 similar patients followed by observation. RESULTS: Doubling of the visual angle occurred in 68% of all cases with 2 years of follow-up. At 6 months, 8 of 19 (42%) treated but no observed cases experienced > or = 1 Snellen line improvement in visual acuity (P = 0.005, Fischer's exact test), and the visual angle was halved in 3 of 19 (16%) treated but no observed cases at 6 months (P = 0.069). Resolution of macular edema occurred at 6 months in 5 of 19 (26%) treated and 1 of 23 (4%) observed cases (P = 0.21). No significant difference in visual acuity between the two groups was present after 2 years. CONCLUSIONS: Progressive visual loss secondary to radiation-induced macular edema is rapid and severe. Focal laser therapy may modestly improve visual acuity and promote resolution of macular edema at 6 months, but benefit from single treatment is not sustained at 2 years.
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