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  • Title: Synthesis and characterization of a protective peptide-based vaccine against Schistosoma mansoni.
    Author: Tarrab-Hazdai R, Schechtman D, Arnon R.
    Journal: Infect Immun; 1998 Sep; 66(9):4526-30. PubMed ID: 9712813.
    Abstract:
    Two synthetic peptides, corresponding to the N-terminal sequence of the 45-kDa subunit of the protective 9B antigen of Schistosoma mansoni and differing in only one amino acid residue, were synthesized. These peptides were recognized by the protective monoclonal antibody 152-66-9B, as well as by sera of mice and humans infected with schistosomiasis. The peptides were coupled to a protein carrier and used for immunization. One of the peptides, 9B-peptide1, induced in mice significant protection against challenge infection, manifested in a 40 to 50% reduction in worm burden.
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