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  • Title: Association of HLA-B51 subtypes and Behçet's disease in Spain.
    Author: González-Escribano MF, Rodríguez MR, Walter K, Sanchez-Roman J, García-Lozano JR, Núñez-Roldán A.
    Journal: Tissue Antigens; 1998 Jul; 52(1):78-80. PubMed ID: 9714478.
    Abstract:
    We have studied the distribution of the different HLA-B51* alleles among patients with Behçet's disease (BD) and ethnically matched healthy controls in a Spanish population. The serological B51 specificity was increased in BD patients (37.5% versus 15.5% in controls). Among the B51-associated alleles, the frequencies of B*5101 (32%) and 5108 (5.5%) were increased in BD patients with respect to the control frequencies (13% and 1.2% respectively). The fact that different HLA-B51 subtypes are associated with BD could suggest that common motifs shared by HLA-B51-related alleles are involved in the susceptibility to BD or, in the light of recent studies, that a mutation causing the susceptibility to BD occurred in the B*5101 haplotype, close to HLA-B gene, before the divergence of B*5108 from the B*5101 allele.
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