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  • Title: Bioavailability and pharmacokinetics of beta-methyldigoxin after multiple oral and intravenous doses.
    Author: Rietbrock N, Guggenmos J, Kuhlmann J, Hess U.
    Journal: Eur J Clin Pharmacol; 1976 Mar 22; 09(5-6):373-9. PubMed ID: 971702.
    Abstract:
    To obtain true half lives, glycoside elimination from six healthy subjects was studied for 14 days after multiple intravenous doses or oral administration of a daily maintenance dose of beta-methyldigoxin 0.3 mg. After oral or intravenous administration of beta-methyldigoxin ceased, the plasma concentrations declined from the 14th to the 16th days with a half life of 1.7 days. From the 16th to the 20th day a change from a shorter to a longer half life of 2.8 and 2.9 days was observed. Similar half lives were found in urine: after the last dose the initial slope from the 14th to the 16th day had a half life of 1.8 days, and the terminal slope had one of 3.2 days. The results indicate release of the glycoside from slowly equilibrating tissues.
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