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  • Title: On the metabolism of prostaglandins by rat brain homogenate.
    Author: Kröner EE, Peskar BA.
    Journal: Experientia; 1976 Sep 15; 32(9):1114-5. PubMed ID: 971735.
    Abstract:
    Using radio-immuno assays for prostaglandins and prostaglandin metabolites, three prostaglandin metabolizing enzymes were found in the 100,000 X g supernatant of rat brain, 15-hydroxy-prostaglandin-dehydrogenase, delta13-reductase and prostaglandin E-9-keto-reductase. Specific activity of the latter enzyme was highest in striatum and midbrain and lowest in cortex, cerebellum and spinal cord.
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