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  • Title: Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes.
    Author: Zhai S, Dai R, Wei X, Friedman FK, Vestal RE.
    Journal: Life Sci; 1998; 63(8):PL119-23. PubMed ID: 9718089.
    Abstract:
    Flavonoids are a class of dietary phytochemicals with anticarcinogenic properties. A series of ten structurally related flavonoids were evaluated for their effect on methoxyresorufin O-demethylase (MROD) activity in human liver microsomes. All compounds inhibited this cytochrome P450 1A2 (CYP1A2) mediated activity. 3,5,7-Trihydoxyflavone (galangin) was the most potent inhibitor, followed by 3-hydroxyflavone and flavone. The relative inhibitory potency of flavonoids is related to their structures. The results suggest that flavonoids may modulate pharmacological and toxicological effects mediated by CYP1A2.
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