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  • Title: Role of hormonal factors in the pathogenesis of postmenopausal osteoporosis.
    Author: Riggs BL, Jowsey J, Kelly PJ, Arnaud CD.
    Journal: Isr J Med Sci; 1976 Jul; 12(7):615-9. PubMed ID: 972016.
    Abstract:
    In 47 women with postmenopausal osteoporosis, pretreatment studies by microradiography, radioimmunoassay and other methods showed increased bone resorption, normal bone formation, and decreased serum immunoreactive parathyroid hormone (PTH). In patients treated with a physiologic replacement dose of estrogen, bone resorption decreased to normal and PTH increased after short-term therapy; bone formation decreased to very low levels after long-term therapy. These data indicate that, in most patients, both an intrinsic abnormality of bone cell function and a disruption of the normal regulation of bone turnover by PTH and sex hormones, as a result of the menopause, are important in the pathogenesis of osteoporosis.
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