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  • Title: Mifepristone and misoprostol for termination of early pregnancy.
    Author: Randel J, French L.
    Journal: J Fam Pract; 1998 Aug; 47(2):96-7. PubMed ID: 9722793.
    Abstract:
    The safety and efficacy of a medical regimen for early pregnancy termination comprised of mifepristone (600 mg orally on day 1) and misoprostol (400 mcg orally on day 3) were assessed in a convenience sample of 2121 US women from 17 abortion clinics. All pregnancies were under 63 days' duration. The regimen had an overall success rate of 85%. This rate dropped from 92% among the 859 women with pregnancies under 50 days' gestation to 83% among the 722 women with pregnancies of 50-56 days' length to 77% in the 540 women whose pregnancies were of 57-63 days' gestation. According to logistic regression analysis, only days pregnant and previous elective abortions were significant predictors of this regimen's success. The regimen was less effective in all gestational age groups for women who had undergone previous induced abortion. Side effects included excessive vaginal bleeding, abdominal pain, headache, nausea, vomiting, and diarrhea. Although a randomized controlled trial of this regimen compared to methotrexate is needed and optimal dosages must be determined, these preliminary findings suggest a mifepristone-misoprostol regimen is especially effective in terminations of pregnancies of less than 50 days.
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